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D2C Peptides
KPV vial

KPV 10 mg

Also searched as: kpv peptide

Sold as KPV - 10mg

$60 In stock

Strength

For research use only. Not for human or veterinary use.

Ships from the USA. Shipping details

KPV is a short peptide of three amino acids, lysine, proline and valine, that matches positions 11 to 13 of alpha-melanocyte-stimulating hormone (alpha-MSH).12 FDA reports it can be made by solid-phase peptide synthesis and is not a component of any FDA-approved drug.3 This vial holds 10 mg of a white freeze-dried solid, as the supplier describes it.4

Specifications

SequenceLys-Pro-Val (L-lysyl-L-prolyl-L-valine, H-Lys-Pro-Val-OH); one-letter code KPV56
Other namesalpha-MSH (11-13), Msh (11-13), ACTH-(11-13), lysyl-prolyl-valine52
Molecular formulaC16H30N4O4 (free base); the acetate salt adds one acetic acid (CH3COOH)273
Molar mass342.43 g/mol for the free base (342.4344 in FDA's substance registry); 402.5 g/mol for KPV acetate273
CAS number67727-97-3 (most public references use the same number for KPV acetate)83
FDA UNII7V6LGD8S5R (record created August 11, 2026)7
PubChem CID1256722
FormWhite freeze-dried (lyophilized) solid, per the supplier4
Salt formNot stated by the supplier; its listed formula and molar mass (342.4 g/mol) match the free base92
Vial contents10 mg per vial; no diluent included4
Strength10 mg
Ships fromUSA
CategoriesAnti-Aging Peptides, Healing and Recovery Peptides
StorageThe supplier lists a shelf life of 36 months at -20 °C or 30 days at 2 to 8 °C, and says a mixed solution must be kept refrigerated at 2 to 8 °C.4 These are supplier statements, not independent stability data.4

Supplies for KPV

Bulk and wholesale orders

Labs that need KPV in larger quantities can apply for a wholesale account. Bulk terms are confirmed on application.

Wholesale detailsApply for a wholesale account

Questions about KPV

About KPV

KPV is a tripeptide, a chain of three amino acids: lysine, proline and valine.6 It is the tail end of alpha-MSH, a 13-amino-acid hormone, which is why PubChem files it as Msh (11-13).12 A 2010 review reports that, in lab and animal models, KPV keeps almost all of the anti-inflammatory capacity of alpha-MSH but none of its pigment action.11

Much of the research is in mice with colitis, where KPV enters gut and immune cells through PepT1, a transporter for small peptides.613 FDA's 2026 review found no clinical studies, case reports or human exposure data for KPV by any route.3 KPV for sale here is a 10 mg research vial; the selector shows the KPV price and stock. For mechanisms, side effects and the full source list, read What is KPV? before you buy KPV for a study.

Research highlights

  • Mouse colitis (2008, 10 mice per group): KPV in drinking water reduced two chemically induced forms of colitis, with lower pro-inflammatory cytokine expression.126
  • Recovery from colitis (2008, mice): treated mice recovered sooner and regained more weight, and all treated mice lacking working MC1 receptors survived.13
  • Nanoparticle delivery (2010, mice): KPV packed into colon-targeted nanoparticles matched free KPV's effect at a 12,000-fold lower concentration.14
  • Colon tumors (2016, mice): KPV prevented colitis-linked tumors in normal mice but had no effect in mice without PepT1.15
  • Brain injury (2013, mice): one injection after the injury gave smaller lesions and less nerve-cell death.16
  • Mouth sores after chemotherapy (2021, rats): a gum gel carrying KPV and the plant compound EGCG improved eating, weight recovery and tissue repair.17

Regulatory status

KPV is not an approved drug.3 FDA's review dated May 12, 2026 says it has no USP or NF monograph and is not a component of any FDA-approved drug, and a Drugs@FDA search on October 24, 2026 found no approved KPV product.318 RAPS reported that on July 23, 2026, FDA's Pharmacy Compounding Advisory Committee voted 8 to 6, with 1 abstention, to recommend adding BPC-157 and KPV to the 503A bulks list, against the advice of FDA staff.19 NCPA reported that the votes are not binding on FDA and that pharmacies may not compound KPV until final rulemaking is in place.20 USADA's guide to the 2027 WADA Prohibited List, in force from January 1, 2027, does not name KPV but says that list names peptides in general under class S0.21

Handling and storage

Solubility depends on the salt form. Citing vendor documents, FDA reports that KPV free base dissolves in water only up to 0.70 mg/mL, while KPV acetate dissolves at 5 mg/mL.3 The supplier does not name its form, though its listed formula and molar mass match the free base.92 At those limits, 10 mg would need about 14.3 mL of water as free base, or 2 mL as acetate, to dissolve fully (our arithmetic). Under acid, alkali and peroxide stress, KPV breaks down mainly into lys-pro-diketopiperazine.22

The reconstitution guide covers the lab steps, and the reconstitution calculator turns a vial amount and a diluent volume into a concentration. KPV is filed under anti-aging peptides and healing and recovery peptides, within the full research peptides range.

Frequently asked questions

How much does KPV peptide cost?

KPV comes as one 10 mg research vial, and the KPV price is $60. The selector at the top of the page shows the current figure and stock status. Bacteriostatic water is not included with the vial and is sold separately.4 Larger orders go through a wholesale account.

Is KPV 10mg available for sale?

Yes, as a research compound only. Every vial is labeled: For research use only. Not for human or veterinary use. KPV is not an approved medicine, and FDA's 2026 review found no clinical studies of it in people.3 Health Canada lists KPV among unauthorized injectable peptides it has seized, and says a research-use label does not make such a product legal in Canada.10

Where does KPV ship from?

D2C Peptides ships across the United States. Ship-from origins differ between products, so the selector at the top of this page shows where the KPV vial ships from and whether it is in stock. The shipping page covers delivery, and the returns page covers return terms.

How should KPV be stored when it arrives?

Colder storage gives the longest figures. Citing a vendor's website, FDA's 2026 review reports freeze-dried KPV free base as stable for up to 3 years at -20 °C in a tightly closed container, 2 years at 4 °C and 3 months at 15 °C.3 No independent study of mixed KPV was found. Sealed and mixed vials are covered in How to store peptides.

Is there a certificate of analysis for KPV?

Lab documents for our products are on the lab results page. FDA found that most certificates for KPV free base report only a purity result, with no impurity limits, and it could not tell whether microbiological tests are in place.3 Because different salts and derivatives are sold as KPV, check which form a certificate names: free base (342.43 g/mol) or acetate (402.5 g/mol).32

What supplies are used with the KPV vial?

The supplier says the powder must be mixed with bacteriostatic water, which is not included.9 The supplies listed for this vial are bacteriostatic water, a 3 mL Luer-Lok syringe, an 18G 1-inch needle, insulin syringes and alcohol swabs. All of these are for lab handling, not for use in people.

Written by D2C Peptides Editorial Team.

Pending qualified review.

Updated .

Sources

  1. Antimicrobial effects of alpha-MSH peptides (Cutuli M et al.) [PMID 10670585]. Journal of Leukocyte Biology (abstract via NLM PubMed E-utilities), 2000.
  2. PubChem compound properties: CID 125672 (Msh (11-13), KPV). National Center for Biotechnology Information (NIH/NLM), PubChem PUG REST, 2026.
  3. FDA Evaluation of KPV-Related Bulk Drug Substances (KPV (Free Base) and KPV acetate) for Inclusion on the 503A Bulk Drug Substances List, FDA briefing document for the July 23-24, 2026 PCAC meeting (memo dated 5/12/2026). U.S. Food and Drug Administration, 2026.
  4. Supplier product specification.
  5. PubChem synonyms: CID 125672. National Center for Biotechnology Information (NIH/NLM), PubChem PUG REST, 2026.
  6. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation (Dalmasso G et al.) [PMID 18061177]. Gastroenterology (abstract via NLM PubMed E-utilities), 2008.
  7. Global Substance Registration System record: L-lysyl-L-prolyl-L-valine, UNII 7V6LGD8S5R (full view). U.S. Food and Drug Administration / NCATS, GSRS, 2026.
  8. PubChem CAS record: Msh (11-13), CID 125672 (sources ChemIDplus, EPA DSSTox, FDA GSRS). National Center for Biotechnology Information (NIH/NLM), PubChem PUG View, 2026.
  9. Supplier product specification.
  10. Think twice before injecting peptides bought online: unauthorized products can seriously harm you (public advisory, 2026-04-09). Health Canada (Recalls and safety alerts), 2026.
  11. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore (Brzoska T et al.) [PMID 21222263]. Advances in Experimental Medicine and Biology (abstract via Europe PMC REST API), 2010.
  12. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation (Dalmasso G et al.), full text [PMC2431115]. Gastroenterology (full text via PubMed Central, NIH/NLM), 2008.
  13. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease (Kannengiesser K et al.) [PMID 18092346]. Inflammatory Bowel Diseases (abstract via NLM PubMed E-utilities), 2008.
  14. Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model (Laroui H et al.) [PMID 19909746]. Gastroenterology (abstract via NLM PubMed E-utilities), 2010.
  15. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model (Viennois E et al.) [PMID 27458604]. Cellular and Molecular Gastroenterology and Hepatology (abstract via NLM PubMed E-utilities), 2016.
  16. Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice (Schaible EV et al.) [PMID 23940690]. PLoS One (abstract via NLM PubMed E-utilities), 2013.
  17. In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis (Shao W et al.) [PMID 34846053]. Biomaterials Science (abstract via NLM PubMed E-utilities), 2021.
  18. openFDA Drugs@FDA API query: products with active ingredient KPV, LYSYL-PROLYL-VALINE or LYSINE-PROLINE-VALINE (HTTP 404, no matches). U.S. Food and Drug Administration (openFDA), 2026.
  19. FDA advisory committee backs two controversial peptides (23 July 2026). Regulatory Affairs Professionals Society (RAPS), 2026.
  20. FDA advisory committee nominates six peptides for pharmacies to compound (July 31, 2026). National Community Pharmacists Association (NCPA), 2026.
  21. Athlete Advisory: What's New on the 2027 WADA Prohibited List? (undated page; 2027 list in force January 1, 2027). U.S. Anti-Doping Agency (USADA), 2026.
  22. Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates (Pawar KR et al.) [PMID 25298219]. Biomedical Chromatography (abstract via NLM PubMed E-utilities), 2015.
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