NAD+ 500 mg

About NAD+

NAD+ (nicotinamide adenine dinucleotide) is two nucleotides, one carrying nicotinamide and one carrying adenine, joined by a pyrophosphate link.¹ It carries electrons by switching between an oxidized form (NAD+) and a reduced form (NADH), which puts it at the center of energy metabolism.¹² Enzymes outside that redox work, including sirtuins and PARPs, also need it as a cofactor.² Cells build NAD+ from the amino acid tryptophan or from vitamin precursors such as nicotinic acid, and recycle it from nicotinamide through a salvage pathway.²

NAD+ is not a peptide,¹ even though the shop places it in the Anti-Aging Peptides and Cognitive Peptides categories. Those names describe research topics, not proven effects. The authors of a 2026 study state that human data on the efficacy and health effects of IV NAD+ remain limited.¹¹ The NAD+ for sale here is one sealed vial of the freeze-dried solid described in the specifications. For a plain-language overview, read What is NAD+?

Research highlights

• Slow IV infusion. In a 2019 randomized pilot of 11 healthy men aged 30 to 55 (8 given NAD+, 3 given saline), 750 mg infused over 6 hours caused no adverse events. Plasma NAD+ did not rise for at least the first 2 hours and was 398% above baseline only at the 6 hour mark.¹²
• Daily IV infusions. In a 2026 retrospective review, all 6 clinic clients given 500 mg by IV daily for 4 days had moderate to severe symptoms during infusions. The symptoms ended with the drip.¹¹
• Three injection routes. In a 2026 preprint, groups of 4 to 6 adults received 100 mg by IV push, intramuscular or subcutaneous injection. No attributable unexpected adverse events were reported, and the paper has not been peer reviewed.¹³
• Levels and age. In skin samples from 49 people, older men and women had lower NAD+. The pattern is a correlation, not proof that falling NAD+ drives aging.²¹⁴
• Oral precursor. In a 2018 randomized crossover trial (30 adults aged 55 to 79), oral nicotinamide riboside for 6 weeks was well tolerated and raised NAD+ metabolism.¹⁵
• The wider picture. A 2023 review of human trials concluded that oral nicotinamide riboside has shown few clinically relevant effects.¹⁶

Regulatory status

FDA has not approved NAD+ as a drug.³ On FDA's 503A list updated May 14, 2026, it is in Category 1, substances still under evaluation.¹⁷ That is an enforcement policy, not an approval: FDA does not intend to act against licensed pharmacies or physicians compounding with such a substance, when its conditions are met, until a final rule decides its status.¹⁸ In October 2024, FDA warned that compounders were making IV products from food-grade NAD+ sold by repackagers.¹⁹ Reports to FDA after NAD+ injections included severe chills, shaking and vomiting, which FDA said fit excess endotoxins.¹⁹ This vial is sold for research use only.

Handling and storage

Before you buy NAD+ online, plan for cold, dry and dark storage from the day the vial arrives.⁷ The vial ships dry and is reconstituted before lab use. The NAD+ reconstitution page covers diluents, concentration math and storage after mixing, and the reconstitution calculator does the arithmetic. Timing matters after mixing: in 2022, one pharmacy recalled multi-dose 500 mg NAD+ vials that were subpotent or past their reconstitution time.²⁰ Label each vial with the date and time it was mixed. The NAD+ price covers the vial alone; diluent and syringes are separate supplies.