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Kisspeptin-10 vial

Kisspeptin-10 5 mg

Also searched as: kisspeptin, kisspeptin 10

Sold as Kisspeptin-10 - 5mg

$40 In stock

Strength
Ships from

For research use only. Not for human or veterinary use.

Ships from the USA or Canada. Shipping details

Kisspeptin-10 is a 10-amino-acid peptide, the fully active end piece of kisspeptin-54, a hormone made from the human KISS1 gene.12 It activates the kisspeptin receptor (KISS1R, also called GPR54); studies in rodents and monkeys show it acts directly on the brain's GnRH nerve cells.223 The vial holds 5 mg of Kisspeptin-10. Human studies have been small (4 to 46 people) and brief: single doses or infusions of up to 22.5 hours.45 No kisspeptin product is FDA approved.6

Specifications

Sequence (one-letter code)YNWNSFGLRF-NH2 (C-terminal amide)72
Sequence (three-letter code)H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH27
Molecular formulaC63H83N17O148
Molar mass1302.4 g/mol8
CAS number374675-21-57
PubChem CID252402978
Position in precursorResidues 112 to 121 of human KISS1 (UniProt Q15726), also called metastin 45-5429
Vial contents5 mg per vial
Strength5 mg
Ships fromUSA, Canada
CategoryReproductive Health Peptides
StorageIn a 2015 UK trial, freeze-dried kisspeptin vials were stored at -20 °C until they were reconstituted.10 For freeze-dried peptides in general, Bachem advises keeping them below -15 °C for longer storage.19

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Questions about Kisspeptin-10

About Kisspeptin-10

Kisspeptin-10 is the last 10 amino acids of kisspeptin-54 (also called metastin): positions 112 to 121 of the human KISS1 precursor in UniProt, ending in phenylalanine amide.2 In rodent and monkey studies, kisspeptin acted directly on GnRH-releasing nerve cells in the hypothalamus through its receptor. That GnRH makes the pituitary release LH and FSH, the hormones that drive the testes and ovaries.3 GnRH itself is listed here as gonadorelin, in the Reproductive Health Peptides range.

This page lists kisspeptin for sale as a 5 mg research vial; the options above show the kisspeptin price, stock and shipping origins. For the mechanism, side effects and full source list, read What is Kisspeptin-10? before you buy kisspeptin online for a study.

Research highlights

  • Fast LH rise, 6 healthy men (2011): single IV doses raised LH rapidly, peaking within 45 minutes; the rise was significant at 4 of the 6 doses tested, but not at the highest.162425
  • Testosterone during infusion, 4 healthy men (2011): over a 22.5-hour IV infusion, testosterone climbed from 16.6 to 24.0 nmol/L.4
  • Sex differences, 11 men and 35 women (2011): IV doses raised LH in men, follicular-phase women responded much less, and injections under the skin did not significantly change their hormones.52627
  • Inherited NKB-pathway defects, 4 patients (2013): during a 12-hour IV infusion, all 4 regained pulsatile LH secretion, with no adverse events related to kisspeptin-10.17
  • Delayed puberty, 16 children (observational, 2020): all 8 whose LH rose by 0.8 mIU/mL or more after one IV test dose later progressed through puberty.1813
  • Head-to-head, healthy men (2015): in 3-hour IV infusions, kisspeptin-10 and kisspeptin-54 had similar effects, while GnRH raised LH and FSH about 3 times more than kisspeptin-10.282930

Regulatory status

Kisspeptin-10 is not FDA approved, and a DailyMed search returns no kisspeptin drug labels.6 On September 29, 2023, FDA put it on its list of compounding substances that may pose significant safety risks, naming possible immune reactions, peptide impurities and limited or no safety data.1431 It remains in 503A Category 2 on FDA's list updated May 14, 2026.11 The WADA 2026 Prohibited List names kisspeptin and its agonist analogues under S2.2.1, banned for male athletes in and out of competition.15 The listing carries this notice: For research use only. Not for human or veterinary use.

Handling and storage

Trial teams reconstituted freeze-dried kisspeptin-10 in sterile 0.9% saline: 0.5 ml per vial in the 2015 UK study, and 1 mg in 5 ml in a 2011 study.1023 For IV infusions, it was dissolved in saline containing 5% gelofusine.32 Its sequence includes asparagine and tryptophan, which Bachem links to a limited shelf life, and GenScript lists tryptophan as prone to oxidation and arginine as prone to absorbing moisture.7192021 Lab steps are in the reconstitution guide, and the reconstitution calculator gives the concentration for a chosen diluent volume.

Frequently asked questions

Where can I get kisspeptin?

Not as a prescription medicine. DailyMed lists no kisspeptin drug label, and FDA's compounding nominations list puts Kisspeptin-10 in Category 2, for substances that raise significant safety risks.611 Massachusetts General Hospital studies gave it under FDA oversight, one under an investigational new drug number.1213 This page lists it as a 5 mg research vial for laboratory work, not for use in people.

Where does Kisspeptin-10 ship from?

Orders ship from the USA and Canada to addresses across the United States. The options at the top of this page show the price and stock and let you pick a shipping origin before checkout. Delivery details are on the shipping page, and return terms are on the returns page.

How should Kisspeptin-10 be stored when it arrives?

There is no drug label with official storage directions for kisspeptin.6 For freeze-dried peptides in general, Bachem, a peptide maker, says room-temperature shipping and short-term refrigeration at 4 °C are acceptable, and advises long-term storage below -15 °C.19 Bachem also advises warming a cold vial to room temperature before opening it, because peptides tend to absorb moisture.1920 More in how to store peptides.

What strength is the Kisspeptin-10 vial?

The vial is listed as 5 mg of Kisspeptin-10. That amount is the starting figure for concentration math, and the reconstitution calculator works out the concentration from it and the volume of diluent added. Papers report kisspeptin-10 in mass or in moles: at 1302.4 g/mol, 1 mg is about 768 nanomoles.8

Is there a certificate of analysis for Kisspeptin-10?

Where lab documents exist for this vial, they are on the lab results page. As a benchmark, one trial used GMP-made kisspeptin-10 at 97% purity by HPLC,23 and a Massachusetts General Hospital team tested reconstituted aliquots for sterility, pyrogens, purity and concentration.12 FDA lists peptide impurities and characterization among its kisspeptin-10 concerns, so check which tests a certificate covers.14

What supplies are used with a Kisspeptin-10 vial?

The supplies listed with this vial are bacteriostatic water, a 3 mL Luer-Lok syringe, an 18G 1-inch needle, insulin syringes and alcohol swabs. Published trials dissolved kisspeptin-10 in sterile 0.9% saline.1023 These are lab handling supplies, not directions for use in people.

Is Kisspeptin-10 for human use?

No. It is sold for laboratory research only, and the listing carries this notice: For research use only. Not for human or veterinary use. No kisspeptin medicine is approved in the US, and FDA says it does not have enough information to judge whether kisspeptin-10 would harm people.631 WADA also prohibits kisspeptin for male athletes at all times.15

Written by D2C Peptides Editorial Team.

Pending qualified review.

Updated .

Sources

  1. Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies (MacLean et al.), abstract: results. Journal of Clinical Endocrinology and Metabolism (PubMed record via NCBI E-utilities), 2014.
  2. KISS1_HUMAN (Q15726): Metastasis-suppressor KiSS-1, peptide features. UniProt Consortium (UniProtKB/Swiss-Prot), 2026.
  3. The kisspeptin-GnRH pathway in human reproductive health and disease (Skorupskaite, George, Anderson). Human Reproduction Update (PMC), 2014.
  4. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men (George et al.): 22.5-hour infusion. Journal of Clinical Endocrinology and Metabolism (PMC), 2011.
  5. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans (Jayasena et al.): participants and doses. Journal of Clinical Endocrinology and Metabolism (PMC), 2011.
  6. DailyMed search results for kisspeptin. DailyMed, NIH/NLM, 2026.
  7. Kisspeptin-10 (CID 25240297): full compound record. PubChem, NIH/NLM, 2026.
  8. Kisspeptin-10 (CID 25240297): computed properties. PubChem, NIH/NLM, 2026.
  9. Kisspeptin-10 (CID 25240297): synonyms. PubChem, NIH/NLM, 2026.
  10. Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men (Jayasena et al.): materials and storage. Human Reproduction (PMC), 2015.
  11. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act (category lists). U.S. Food and Drug Administration, 2026.
  12. Kisspeptin Resets the Hypothalamic GnRH Clock in Men (Chan et al.): oversight and peptide testing. Journal of Clinical Endocrinology and Metabolism (PMC), 2011.
  13. Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay (Chan et al.): methods. Journal of Clinical Endocrinology and Metabolism (PMC), 2020.
  14. Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (Kisspeptin-10 entry). U.S. Food and Drug Administration, 2026.
  15. Tractatenblad 2026, 25: Anti-Doping Convention annex, the 2026 Prohibited List (official text). Tractatenblad van het Koninkrijk der Nederlanden (Dutch Treaty Series), text of the WADA 2026 Prohibited List, 2026.
  16. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men (George et al.), abstract. Journal of Clinical Endocrinology and Metabolism (PubMed record via NCBI E-utilities), 2011.
  17. Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies (Young et al.): dosing and safety. Neuroendocrinology (PMC), 2013.
  18. Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay (Chan et al.), abstract. Journal of Clinical Endocrinology and Metabolism (PubMed record via NCBI E-utilities), 2020.
  19. Handling and Storage Guidelines for Peptides (Peptide Guide, chapter 8). Bachem.
  20. Care and Handling of Peptides. Bachem, 2021.
  21. Peptide Storage and Handling Guidelines. GenScript.
  22. Same source as 2: function.
  23. Same source as 4: peptide preparation.
  24. Same source as 4: bolus study.
  25. Same source as 4: dose response.
  26. Same source as 5: testosterone and sex differences.
  27. Same source as 5: responses in women.
  28. Same source as 10: design.
  29. Same source as 10: safety and conclusion.
  30. Same source as 10: potency and cost.
  31. Same source as 14: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (Kisspeptin-10 safety information).
  32. Same source as 5: half-life and infusion preparation.
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