Staging preview: health content pending qualified review
D2C Peptides
Cardiogen vial

Cardiogen 20 mg

Sold as Cardiogen 20mg

$55 In stock

Strength
Ships from

For research use only. Not for human or veterinary use.

Ships from the USA or Canada. Shipping details

Cardiogen is a synthetic tetrapeptide, Ala-Glu-Asp-Arg (AEDR), from Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology in Russia, which links it to cardiovascular function.12 Published work is cell and tissue culture plus a few rat studies, and no human study was found.345 It is not FDA approved.6 Each vial holds 20 mg of freeze-dried powder for laboratory research.7

Specifications

Sequence (one-letter code)AEDR18
Sequence (three-letter code)H-Ala-Glu-Asp-Arg-OH28
PubChem recordNot confirmed for AEDR; a PubChem name search for 'cardiogen' returns (-)-carnitine, CID 10917, a different molecule9
FormFreeze-dried (lyophilized) powder7
Vial contents20 mg per vial7
DiluentNot included; bacteriostatic water is sold separately7
Strength20 mg
Ships fromUSA, Canada
StorageStore the sealed vial refrigerated and protected from light, as the supplier advises.7 For long-term storage, GenScript, a peptide maker, gives -20 °C away from bright light as its general condition for freeze-dried peptides.10

Supplies for Cardiogen

Bulk and wholesale orders

Research groups that need Cardiogen for repeated tissue culture runs can apply for a wholesale account. Volume terms are confirmed on application.

Wholesale detailsApply for a wholesale account

Questions about Cardiogen

About Cardiogen

Cardiogen is a lab-made peptide of four amino acids: alanine, glutamic acid, aspartic acid and arginine (Ala-Glu-Asp-Arg, or AEDR).2 Vladimir Khavinson's group in St. Petersburg reports finding AEDR in a polypeptide complex extracted from heart tissue.8 The group lists it as a regulator of cardiovascular function.1 This page offers Cardiogen for sale as a 20 mg research vial, with stock for each shipping origin in the selector above.

The name causes confusion. CardioGen-82 is an unrelated FDA-approved product, a generator of the radioactive imaging agent rubidium Rb 82 used in heart PET scans.11 A PubChem name search for "cardiogen" also returns the wrong molecule, (-)-carnitine.9 Before you buy Cardiogen for a study, read What is Cardiogen? for the full evidence and its gaps.

Research highlights

  • Rat heart tissue, young and old (2009): at 1 picomolar (10^-12 M), cardiogen strongly stimulated cell growth in tissue from 3- and 24-month-old rats.3 It also lowered p53, a protein linked to programmed cell death.3
  • Rat heart explants (2006): 0.05 ng/ml stimulated growth of heart tissue from 3-week-old and 18-month-old rats compared with untreated controls.12
  • Mouse embryonic fibroblasts (2012): AEDR raised cytoskeleton proteins (actin, tubulin, vimentin) 2 to 5 fold and lamin A and C 2 to 3 fold.2
  • Rats with induced heart attack, reported in a 2022 review: AEDR cut deaths threefold compared with controls.8 For these data the review cites a US patent, not a peer-reviewed study.8
  • Old rats with transplanted sarcoma (2009): cardiogen slowed tumor growth in a dose-dependent way, apparently by acting on the tumor's blood vessels.4
  • Human prostate fibroblasts (2010): in aging cultures, cardiogen raised the signaling proteins CXCL12, WEDC1 and ghrelin, though another peptide, T-38, was the most active.13

Regulatory status

The Cardiogen peptide is not FDA approved: an October 2026 search of FDA's approval data found no product with it as an active ingredient.6 It is not on FDA's May 14, 2026 list of bulk substances nominated for compounding under section 503A.14 Health Canada's August 1, 2025 advisory on unauthorized injectable peptides does not name Cardiogen, though it names other short peptides such as Pinealon and Livagen.15 The advisory says injectable peptides are regulated as prescription drugs in Canada and that selling unauthorized drugs is illegal there.15 WADA's 2026 list does not name Cardiogen, but its class S0 bans at all times any substance not covered by the list's other sections that has no government approval for human therapeutic use.16 The 2027 list, in force January 1, 2027, adds peptides to the S0 examples.17

Handling and storage

The supplier says to reconstitute Cardiogen with bacteriostatic water, keep it refrigerated and use it within 30 days.7 That is supplier guidance, not published stability data.7 GenScript says peptide solutions keep for a much shorter time than powder, especially when the sequence contains Asp, as Cardiogen's does.10 For concentration work, Bachem notes that freeze-dried peptide powder may be only 70 to 90% peptide by weight.18 The reconstitution guide covers the lab steps, and the reconstitution calculator does the math.

Frequently asked questions

Where does Cardiogen ship from?

Orders ship from the USA and Canada to addresses across the United States. The selector at the top of the page shows each shipping origin for this vial and its stock status. Check it before checkout, because stock can differ by origin. Delivery details are on the shipping page, and return terms are on the returns page.

How should Cardiogen be stored when it arrives?

Refrigerate the sealed vial on arrival and keep it away from light, as the supplier advises.7 GenScript notes that peptides containing Asp, Glu or Arg tend to pull moisture from the air, and Cardiogen contains all three.10 Let a cold vial reach room temperature before opening it, weigh out what is needed quickly and reseal it tightly.10 Details are in How to store peptides.

Is Cardiogen the same as CardioGen-82?

No. CardioGen-82 is an FDA-approved generator from Bracco Diagnostics. It produces rubidium Rb 82, a radioactive agent for PET imaging of heart blood flow in adults with suspected or known coronary artery disease.11 The Cardiogen on this page is the AEDR research peptide, which is not an FDA-approved drug.6 Check the name and the sequence, Ala-Glu-Asp-Arg, on any order or document.

Is there a certificate of analysis for Cardiogen?

See the lab results page for the store's certificate information. When you read a Cardiogen certificate, confirm that it describes the sequence Ala-Glu-Asp-Arg. A PubChem name search for 'cardiogen' points to (-)-carnitine (CID 10917, formula C7H15NO3).9 That is a different molecule, so identity data must not be taken from that entry.9

Is Cardiogen for human use?

No. The supplier sells Cardiogen only for lab research, and its label rules out human and veterinary use.7 No human dose is established, and no clinical trial of the Cardiogen peptide is registered; the records a 'cardiogen' search returns are unrelated.65 Its safety in people, including people with heart disease, has not been studied.5

Written by D2C Peptides Editorial Team.

Pending qualified review.

Updated .

Sources

  1. Khavinson V, et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021;26(22):7053 (PMC8619776). Molecules (MDPI); full text via PMC (NLM), 2021.
  2. Khavinson VKh, et al. Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins. Bull Exp Biol Med. 2012;153(4):559-62. Bulletin of Experimental Biology and Medicine; record via PubMed (NLM), 2012.
  3. Chalisova NI, et al. The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats. Adv Gerontol. 2009;22(3):409-13 (in Russian). Advances in Gerontology; record via PubMed (NLM), 2009.
  4. Levdik NV, Knyazkin IV. Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. Bull Exp Biol Med. 2009;148(3):433-6. Bulletin of Experimental Biology and Medicine; record via PubMed (NLM), 2009.
  5. ClinicalTrials.gov search: 'cardiogen' (API v2). ClinicalTrials.gov, National Library of Medicine (NIH), 2026.
  6. openFDA Drugs@FDA search: active ingredient 'cardiogen'. U.S. Food and Drug Administration (openFDA), 2026.
  7. Supplier product specification.
  8. Khavinson V, et al. Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation. Cells. 2022;12(1):106 (PMC9818427). Cells (MDPI); full text via PMC (NLM), 2022.
  9. PubChem name lookup: 'cardiogen' (returns CID 10917, (-)-Carnitine). PubChem, National Library of Medicine (NIH), 2026.
  10. Peptide Storage and Handling Guidelines. GenScript.
  11. CARDIOGEN-82 (rubidium chloride Rb-82) injection, solution: prescribing information (Bracco Diagnostics Inc.). DailyMed, National Library of Medicine (NIH), 2026.
  12. Zakutskii AN, et al. The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats. Adv Gerontol. 2006;19:93-6 (in Russian). Advances in Gerontology; record via PubMed (NLM), 2006.
  13. Kheifets OV, et al. Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging. Adv Gerontol. 2010;23(1):68-70 (in Russian). Advances in Gerontology; record via PubMed (NLM), 2010.
  14. Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act (updated May 14, 2026). U.S. Food and Drug Administration, 2026.
  15. Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks (public advisory, 2025-08-01). Health Canada (Recalls and safety alerts), 2025.
  16. World Anti-Doping Code International Standard: Prohibited List 2026. World Anti-Doping Agency (WADA), 2025.
  17. World Anti-Doping Code International Standard: Prohibited List 2027. World Anti-Doping Agency (WADA), 2026.
  18. Care and Handling of Peptides. Bachem, 2021.
Shop all peptides